Neuronal Survival
and Degeneration
Maor-Nof Lab
We study neurons, dendrites and axons, the unique structures that connect neurons to each other and to their targets. Most neurons have to survive and continue to function effectively throughout the entire life of the organism for 70 or more years in the case of neurons in the human brain. How do these neurons survive? How do they age? How do they die? Why some of them are susceptible to degeneration while others not?
Our lab employs a wide array of cellular and animal models to understand the mechanisms underlying neuronal fate from normal development to neurodegenerative disease. We use a wide array of cellular, molecular, genomics, proteomics, and computational methodologies to study neuronal fate and axonal state. We harness these insights to promote neuronal and axonal survival.
